Caring for Someone with Alzheimer's Disease and Agitation?
Clinical Trials May Help Explore Potential Treatment Options
Agitation is one of the most common neuropsychiatric symptoms of Alzheimer’s disease. It is generally described as emotional distress accompanied by excessive motor activity, verbal outbursts, or aggressive behavior that is not explained by another medical or psychiatric condition. Reported estimates suggest agitation affects a substantial share of people living with Alzheimer’s dementia at some point in the course of the disease.
Agitation can appear at any stage but is often more frequent and more severe as the disease progresses. It may show up as pacing, restlessness, repeated questioning, resistance to personal care, verbal outbursts, or physical aggression. These symptoms can disrupt daily routines, increase safety risks at home, and add significant strain for family members and caregivers.
If you are caring for an adult with Alzheimer’s disease who experiences agitation, Revival Research Institute is conducting Agitation in Alzheimer’s Clinical Trials to evaluate an investigational treatment approach for adults living with this condition.
Are You Eligible to Participate?
To qualify for the Agitation in Alzheimer’s Clinical Trials, participants must:
- Be an adult male or female ≥ 55 and 90 years of age
- Have a clinical diagnosis of Alzheimer's with agitation disease
- Have shown signs of agitation for at least 4 weeks
- Have been living in the same setting for at least 6 weeks
*Additional criteria may apply.
Participation is free of cost. To learn more or determine whether your loved one may qualify, complete the form below. A member of our research team will contact you to discuss potential eligibility.
About Agitation in Alzheimer's Clinical Trials
Managing agitation in Alzheimer’s disease often requires a combination of caregiver strategies, environmental adjustments, and ongoing medical supervision. Because symptoms can change in frequency and intensity over time, families frequently look for additional options beyond what is currently available.
Revival Research Institute is conducting Alzheimer’s with Agitation Research Studies in Texas for adults with a clinical diagnosis of Alzheimer’s disease who experience agitation. The study is designed to evaluate the safety and efficacy of an investigational treatment being studied for agitation associated with Alzheimer’s dementia.
*All study-related procedures and study treatments are provided at no cost to eligible participants. No insurance is required to participate.
*To take the next step, submit the form above, and our research staff will contact you to determine if your loved one qualifies. A brief discussion about their health and medical history may be required.
Get Started
What to Expect?
If you are caring for an adult with Alzheimer’s disease and agitation, they may qualify for Agitation in Alzheimer’s Clinical Trials exploring potential treatment options. After completing the interest form above, a member of our research team will contact you for a brief pre-screening discussion to determine whether the initial eligibility requirements are met.
If the participant qualifies, an Informed Consent Form (ICF) will be reviewed and signed. This document explains the study procedures, potential risks, possible benefits, and participant responsibilities before any decision to participate is made. Depending on the participant’s capacity to consent, a legally authorized representative may need to provide consent, with the participant’s assent, in line with the study protocol and applicable regulations.
Once consent is provided, the participant may be invited to one of Revival Research Institute’s study sites for additional screening evaluations. These assessments may include a physical examination, review of medical history, vital signs, laboratory testing, cognitive and behavioral assessments, and other evaluations required by the study protocol.
Participants who meet all study requirements may be enrolled in the study. Our team will make sure you and your loved one fully understand what participation involves and what to expect throughout the study duration. You are encouraged to ask questions at any time.
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Agitation in Alzheimer's Disease
A Common Neuropsychiatric Symptom
Alzheimer’s disease is a progressive neurodegenerative condition that affects memory, thinking, and behavior. Alongside cognitive decline, many people with Alzheimer’s develop neuropsychiatric symptoms, and agitation is among the most frequently reported. It is assessed clinically using caregiver-reported tools and structured behavioral scales rather than a single laboratory test.
Agitation in Alzheimer's May Present Through:
- Restlessness, pacing, or repetitive movement
- Verbal outbursts, shouting, or repeated questioning
- Physical aggression toward self, objects, or others
- Resistance to personal care and daily assistance
- Excessive or purposeless motor activity
- Irritability, sudden mood changes, or visible emotional distress
Common Features Associated with Agitation in Alzheimer's Disease Include:
- Symptoms that fluctuate in frequency and severity over time
- Increased safety risk for the person and those around them
- Disrupted sleep and daily routines
- Higher caregiver burden and emotional strain
- Greater likelihood of an earlier move to residential or supervised care
- Reduced quality of life for both the person and the family
The presentation and severity of agitation can vary depending on the stage of Alzheimer’s disease, the individual’s environment, and other contributing medical factors.
Frequently Asked Questions
Your Guide to Agitation in Alzheimer's Disease
Got questions about agitation in Alzheimer’s disease? You’re not alone.
We’ve compiled answers to some of the most common questions about agitation in Alzheimer’s, including its causes, symptoms, assessment, treatment, and clinical trial participation. Still have questions? Contact our research team for more information. Call us at +1 (248) 721-9539, we’ll be happy to assist you.
