Are Uncontrolled Chronic Hives Holding You Back?
Despite the Allergy Meds?

A Clinical Research Study for Hives is now Enrolling!

Chronic Spontaneous Urticaria also known as Spontaneous Hives, is constant red, itchy welts that result from a skin reaction. This lasts for approximately 6 weeks or more, without any cause. Constant itching is a major concern and has the greatest impact on one’s life.

You may be eligible to participate in the Hives Study if you:
• Are 18 years or older
• Diagnosed with Chronic Spontaneous Urticaria (Chronic Hives)
• Have itch and wheals for 8 consecutive weeks, despite anti-allergy treatments

We’re studying an experimental subcutaneous injectable treatment that may be able to help people suffering from Chronic Urticaria (Hives). This study treatment will be compared to another approved and established Chronic Spontaneous Urticaria treatment.

*This study treatment is not yet approved by the FDA (U.S. Food and Drug Administration). We’re conducting this research trial to study the safety and efficacy of the study drug.

*You may receive a call from one of our research staff and they will ask you about your medical history and medications you use. Your personal information will not be disclosed outside of the organization and will only be accessed by the research staff for research purposes. Learn more about the safety and privacy of your information.

Please provide YOUR contact information only.
Sign Up for a Clinical Trial of Chronic Spontaneous Urticaria Study

About the Hives Study

Revival Research Institute is conducting Phase 3 clinical trials on an experimental drug for people who suffer from chronic Hives and itching, despite taking allergy medications. If you qualify for the research study and decide to participate, there is a 50% chance you might either receive the study drug, or an already approved Chronic Spontaneous Urticaria treatment (by the FDA). The study doctor will explain when, how often and how the study drug will be given to you.

In this study, neither you nor the study doctor will know which study treatment you receive during all assessment points. However, the study doctor may be able to get this information if there is a need. The study drug will be given to you in the form of a subcutaneous injection. In this type of injection, a short needle is used to inject the drug into the tissue layer between the skin and the muscle.

*Volunteers will be invited to the site for a visit to complete the screening process which includes medical assessments and blood tests. If you qualify and decide to participate in the study, you will either receive the study drug or the already approved Chronic Urticaria treatment.

*All eligible participants will receive study-related care from professional healthcare experts including doctors and nurses. If you qualify and decide to participate, you will be monetarily compensated for your time and travel, with no costs to you or your private insurance.

Get Started: What to Expect?

Once volunteers fill the form, they will receive a phone call from one of the research staff. Part of the screening process will take place over the phone call and the rest will be completed once we invite you to the study site, if you qualify. The study doctor will explain the study treatments available to you and conduct certain tests including blood tests, ECG, biomarker analysis for the research study while maintaining the privacy and confidentiality status of all volunteers. You will receive complete study-related care, including the study-related treatments and tests from a professional and experienced healthcare staff including doctors and nurses.

Volunteers who qualify for the research study will be asked to sign an Informed Consent Document after everything about the study including the study treatment, optional treatments, and risks and benefits have been explained by the study doctor. We encourage all volunteers to ask as many questions as possible and to only then sign the Informed Consent document once all their questions have been answered.

*Participation in the Hives Research Study is free of cost to both you and your insurance. All volunteers will receive compensation for time and travel for every visit completed.

Condition

 Cutaneous Lupus Erythematosus

Length of Study Treatment

24 weeks

Number of Study Visits

09

About Chronic Spontaneous Urticaria (Hives)

Chronic Spontaneous Urticaria study

Chronic Urticaria or Uncontrollable Hives is the daily or episodic appearance of wheals and swelling within the deeper layers of the skin (angioedema), without any cause. Deep tissue swelling occurs in about 40% of the patients with Chronic Hives. It is mostly unpredictable and the swelling can occur anywhere on the body or in the upper respiratory tract. Swelling of the face, lips, or airway is particularly uncomfortable and can be very serious. In about 75% of Hives cases, the causes are unknown.

How is Chronic Urticaria treated?

The first line of chronic urticaria treatment usually includes antihistamines. Some of the most common antihistamines with few side effects include:
• cetirizine (Zyrtec)
• loratadine (Claritin)
• fexofenadine (Allegra)
• desloratadine (Clarinex)
• levocetirizine (Xyzal)

If your Hives aren’t clearing up with antihistamines, your doctor might recommend other treatments that could include oral corticosteroids, sedating antihistamines, immunosuppressants, or other medications that may help reduce the symptoms and swelling.

What is the outlook?

Chronic spontaneous urticaria or chronic Hives are very unpredictable and their symptoms can come and go for years. There are many medications your doctor might recommend that may be able to help you with your Hives. However, the symptoms will return once the treatment is stopped. Most of the time, many of the treatments leave unpleasant side effects or they just don’t work out for some people. Your doctor might recommend you for clinical trials on new experimental medications that may be able to help people like you. Clinical trials may be able to provide a solution when no option seems to be working.

Frequently Asked Questions

What is Chronic Spontaneous Urticaria?

Urticaria is the medical term for Hives. In this condition, you see itchy, raised bumps or welts on your skin. When the condition lasts for more than 6 weeks and there are no known causes for it, it is considered Chronic Spontaneous Urticaria (Hives). In about 75% of chronic hives cases, the causes are unknown.

How to treat Chronic Urticaria?

The first line of Chronic Urticaria treatment mostly includes over-the-counter antihistamines. You can treat the itchiness by holding an ice pack to the area. Severe cases of hives will require a prescription of other medications like H2 blockers, immune suppressants, or oral corticosteroids, from a doctor.

Will I have to pay to participate in the Hives Clinical Trial?

Participation in all our clinical research studies including the Hives Clinical Trial is free of cost to both you and your private insurance. If you qualify and decide to participate in the research study, you will be monetarily compensated for your time and travel.

What can I do to reduce my symptoms of Chronic Hives?

Try to avoid common allergy foods like nuts, eggs, shellfish, and food that contain additives and artificial flavors. Medications like aspirin and NSAIDs can also aggravate your Hives. Pay attention to some of the triggers that may cause Hives and try to avoid them. Take cool oatmeal baths and use ice packs – this is known to reduce the swelling and inflammation due to Hives.

Will the study drug cure me of Chronic Hives?

The study drug will not cure you of chronic hives but, it may be able to help reduce the symptoms of hives, which can help improve lives. Revival Research Institute is conducting clinical trials on an experimental drug that could help treat hives symptoms and help many people suffering from this condition.