Living with Chronic Knee Pain Due to Osteoarthritis?
Knee Osteoarthritis Clinical Trials May Help Explore Potential Treatment Options
Knee osteoarthritis (OA) is a progressive joint condition that can cause chronic pain, stiffness, and difficulty with physical functioning. Changes associated with knee OA may include cartilage degradation, osteophyte development, remodeling of joint structures, and inflammation within the joint. Despite available treatment options, some people continue to experience inadequate pain relief or treatment-related side effects.
If you are living with chronic pain due to knee osteoarthritis, Revival Research Institute is conducting Knee osteoarthritis clinical trials evaluating an investigational oral study intervention. The study is designed to evaluate the safety and efficacy of potential drug in adults with chronic pain due to knee OA.
Whether you are searching for a Chronic knee pain clinical trial, a Knee arthritis clinical trial, or opportunities to participate in research, clinical trials may provide an opportunity to contribute to the advancement of potential treatment approaches.
Are You Eligible to Participate?
To qualify for Knee osteoarthritis clinical trials, participants must:
- Be at least 40 years of age at the time of signing informed consent
- Have chronic pain in the index knee for more than 12 weeks
*Additional criteria may apply.
If you are interested in participating in Knee osteoarthritis clinical trial research, complete the form below. A member of our research team will contact you to discuss your potential eligibility.

About Knee Osteoarthritis Clinical Trials
Living with chronic knee osteoarthritis can affect physical function, mobility, and quality of life. Knee OA is associated with changes within the joint that can contribute to persistent pain and stiffness. Current approaches to managing knee OA pain include non-pharmacological therapies, oral and topical analgesics, injections, and other treatment strategies. However, some individuals continue to experience inadequate relief or treatment-related concerns.
Revival Research Institute is conducting a clinical trial evaluating an investigational treatment option, in adults with chronic pain due to knee osteoarthritis.
*All study-related procedures and study treatments are provided at no cost to eligible participants. No insurance is required to participate.
*To take the next step, submit the form above, and our research staff will contact you to determine if you qualify. A brief discussion about your health and medical history may be required.
Get Started
What to Expect?
If you are living with chronic knee pain due to osteoarthritis, you may qualify for Knee osteoarthritis clinical trials exploring a potential approach to pain management. After completing the interest form above, a member of our research team will contact you for a brief pre-screening discussion.
If you qualify, you will be asked to review and sign an Informed Consent Form (ICF). This document explains the study procedures, potential risks, possible benefits, and participant responsibilities before you decide whether to participate.
Once consent is provided, you may be invited to one of Revival Research Institute’s study sites for additional screening evaluations. Screening may include medical history review, physical assessments, laboratory testing, an X-ray of the index knee, and other evaluations required by the study protocol. A research MRI of the index knee is also performed before randomization.
Participants who meet all study requirements may be enrolled in the Knee osteoarthritis clinical trial. Our team will ensure that you fully understand your participation and what to expect throughout the study duration. You are encouraged to ask questions at any time.
Age
Condition
Location
Chronic Pain Due to Knee Osteoarthritis

Knee osteoarthritis is a progressive joint disorder associated with changes to cartilage, bone, and other joint structures. These changes can contribute to chronic pain, stiffness, and reduced physical function. Chronic pain is generally pain that persists for more than three months or beyond the expected period of tissue healing.
How Knee Osteoarthritis May Affect Daily Life
- Persistent or recurring knee pain
- Knee stiffness
- Reduced physical functioning
- Difficulty with movement or activities
- Pain associated with movement
- Effects on quality of life
Common Features Associated with Knee Osteoarthritis Include
- Chronic pain in the affected knee
- Joint stiffness
- Crepitus
- Morning stiffness lasting less than 30 minutes
- Reduced physical function
- Pain that may interfere with everyday activities
Frequently Asked Questions
Your Guide to Knee Osteoarthritis Clinical Trials
Got questions about knee osteoarthritis, chronic knee pain, or clinical research? You’re not alone.
We’ve compiled answers to some of the common questions about knee osteoarthritis and Knee osteoarthritis clinical trials. Still have questions? Contact our research team for more information. Call us at +1 (248) 721-9539 — we’ll be happy to assist you.
What is knee osteoarthritis?
Knee osteoarthritis (OA) is a progressive joint condition involving changes such as cartilage degradation, osteophyte development, remodeling of joint structures, and inflammation. It can cause pain, stiffness, and functional limitations
What is chronic pain due to knee osteoarthritis?
Chronic pain is pain that persists for more than three months or extends beyond normal tissue healing time.
Can adults participate in Knee osteoarthritis clinical trials?
Yes. The study is designed for adults who are at least 40 years of age at the time of signing informed consent and who meet the study's other eligibility requirements, including criteria related to chronic knee pain and radiographic knee osteoarthritis. Additional eligibility criteria may apply.

