Struggling With Chronic Itching with No Clear Cause?
Exploring Clinical Trials for Chronic Pruritus of Unknown Origin
Chronic pruritus of unknown origin (CPUO) is a condition involving persistent itching without an identified underlying cause. Chronic itching can affect comfort, sleep, daily activities, and quality of life. Revival Research Institute is conducting chronic pruritus of unknown origin clinical trials to evaluate potential treatment approaches for adults experiencing chronic pruritus.
If you are experiencing persistent itching without a known cause, chronic pruritus research studies may provide an opportunity to contribute to research exploring potential approaches for managing this condition.
Revival Research Institute is conducting chronic pruritus of unknown origin clinical trials in Michigan to investigate the safety and potential effectiveness of an investigational treatment for adults with chronic pruritus of unknown origin.
You may qualify for the Chronic Pruritus of Unknown Origin Clinical Trial near you if you are:
- Adults 18 to 90 years of age
- Have a history of chronic pruritus for at least 6 months
*Additional Criteria may apply.
*If you are interested in participating in chronic pruritus of unknown origin clinical trials or would like more information, please fill out the form so we can determine if you may qualify for the study and contact you. Participation is entirely voluntary.

About Chronic Pruritus of Unknown Origin Clinical Trials in Michigan
This clinical study is designed to evaluate the efficacy and safety of an investigational treatment for adults with chronic pruritus of unknown origin. The study will assess changes in itching severity and other measures related to chronic pruritus.
Participants will be monitored by an experienced research team throughout the study. Study-related assessments may include medical history, physical examinations, vital signs, laboratory testing, ECGs, pregnancy testing when applicable, questionnaires, and assessments related to itching, sleep, and quality of life.
*Study-related procedures and visits may be provided at no cost to eligible participants. Please speak with the study team for details.
What You Can Expect
Has persistent itching been affecting your comfort, sleep, or daily activities?
If you have chronic pruritus and are interested in chronic pruritus research studies, please reach out by filling in the form above. A member of the research team will contact you to determine whether you may qualify for the study through a pre-screening process.
If you meet the initial study requirements, the research team will provide detailed information about the study and explain the informed consent process. You will have an opportunity to ask questions and review the study information before making your decision.
If you decide to participate, you will be asked to sign an Informed Consent Form (ICF). After providing informed consent, you may be invited to a screening visit at the clinical research site.
Age
Condition
Location
Michigan
About Chronic Pruritus of Unknown Origin Symptoms

Chronic pruritus refers to persistent itching that continues over an extended period. When an underlying cause cannot be identified after appropriate evaluation, it may be classified as chronic pruritus of unknown origin (CPUO). CPUO can affect daily life and may be associated with sleep disruption and reduced quality of life.
Risk Factors for Chronic Pruritus:
- Chronic skin conditions, such as eczema or psoriasis
- Kidney disease
- Liver disease
- Thyroid disorders
- Diabetes mellitus
- Certain medications
Chronic Pruritus Symptoms:
- Persistent or chronic itching
- Moderate to severe itching
- Itching affecting different areas of the body
- Sleep disruption related to itching
- Impact on quality of life
- Recurrent need to manage itching
Frequently Asked Questions
Your Guide to Common Questions
Have a look at some of our most frequently asked questions regarding clinical trials and what they’re all about. If you can’t find the answer you’re looking for, call us at: +1 (248) 721-9539.
What is chronic pruritus of unknown origin?
Chronic pruritus of unknown origin (CPUO) refers to persistent itching for which no clear underlying cause has been identified. CPUO can be challenging to manage because its underlying causes and mechanisms are not always clear.

