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Dealing with Primary Membranous Nephropathy?

Discover Hope Through Clinical Trials

Primary Membranous Nephropathy (PMN) is a rare, immune-mediated kidney condition that causes the kidneys to leak large amounts of protein into the urine; a condition known as proteinuria. Over time, this can lead to nephrotic syndrome, chronic kidney damage, and even kidney failure if left untreated.

PMN is most often associated with antibodies against the phospholipase A2 receptor (PLA2R) found on podocytes, the kidney’s filtration cells. These antibodies trigger an autoimmune response, damaging the filtering units of the kidneys and causing inflammation.

Revival Research Institute is conducting Primary Membranous Nephropathy Clinical Trials to explore innovative treatment options. These studies aim to assess the safety and efficacy of investigational therapy designed to target B cells involved in disease progression. The trial aims to assess the safety and effectiveness of this treatment in slowing or potentially reversing kidney damage caused by PMN.

Are You Eligible to Participate?

To participate in our clinical trial for Primary Membranous Nephropathy, individuals must meet the following criteria:

  • Age between 18 to 70 years
  • Diagnosed with Primary Membranous Nephropathy (PLA2R-positive)
  • Urine protein-creatinine ratio (UPCR) of ≥ 2.0 g/g

*Additional criteria may apply.

Participation in Primary Membranous Nephropathy clinical trials in Texas or other locations provides a chance to receive expert care, free study-related medication, and regular health monitoring by experienced medical professionals.

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About the Clinical Trials for Primary Membranous Nephropathy

Living with Primary Membranous Nephropathy (PMN) can be physically draining and emotionally overwhelming. This rare kidney condition often leads to persistent proteinuria, swelling, fatigue, and long-term concerns about kidney function. Many individuals feel uncertain about treatment options or how to best manage their condition over time.

Revival Research Institute is conducting a clinical research study to evaluate the safety and effectiveness of an investigational treatment for PMN in adults.

The PMN Clinical Trials are being conducted at multiple locations across the United States, including Texas. To determine eligibility, all potential participants will undergo a screening process. Those who qualify and are enrolled in the study will receive either investigational treatment or participate in one of the dose cohorts, as outlined in the trial design.

*All study procedures and study-related treatments, including the investigational drug, are provided at no cost, and no insurance is required to participate, and participants may receive compensation for time and travel.

*To take the next step, submit the form above, and our research staff will contact you to determine if you qualify for the study. A brief discussion about your health and medical history may be required.

Get Started: What to Expect?

If you are living with Primary Membranous Nephropathy (PMN), you may qualify for a compensated clinical trial exploring potential treatment options for this condition. After completing the interest form above, a member of our research team will reach out for a brief pre-screening to assess your initial eligibility. If you meet the preliminary criteria, you will be invited to review and sign an Informed Consent Form (ICF), a document that outlines all study procedures, potential benefits, and associated risks.

Following your consent, you’ll be invited to a screening visit at our clinical research site. During this initial visit, we will ask questions about your medical history, perform physical exams, and run lab tests to further assess your eligibility. If you meet all study requirements, you will be officially enrolled in the clinical trial.

Our team will ensure you fully understand your role in the study and what to expect throughout the process. You are encouraged to ask any questions before enrolling. Your participation helps advance future treatments for early puberty.

Condition

Primary Membranous Nephropathy (PMN)

Age

18 to 70 years

Location

Texas

Understanding Primary Membranous Nephropathy

understanding-primary-membranous-nephropathy

Primary Membranous Nephropathy can be caused by:

  • Immune system dysfunction
  • Genetic predisposition
  • Environmental triggers

Symptoms of Primary Membranous Nephropathy include:

  • Swelling in the legs, ankles, or around the eyes
  • Foamy or frothy urine (a sign of protein loss)
  • Fatigue and low energy levels
  • Shortness of breath (in advanced cases)

The primary treatment for Primary Membranous Nephropathy often includes medications to reduce proteinuria and manage immune activity. Participation in clinical trials for PMN may provide access to investigational therapies aimed at improving kidney function and long-term health outcomes.

Frequently Asked Questions

What is Primary Membranous Nephropathy (PMN)?

PMN is an autoimmune kidney disease where the immune system mistakenly attacks the kidneys, leading to protein leakage in the urine and risk of kidney damage.

How is PMN diagnosed?

Diagnosis involves kidney biopsy, detection of anti-PLA2R antibodies in the blood, and lab tests such as UPCR and eGFR.

What if I’ve used other treatments before?

You may still qualify. Prior treatment with ACEi/ARB is allowed, but use of rituximab or similar B-cell depleting agents within 24 weeks prior is not.

Is this trial safe?

In prior studies, investigational drug was well tolerated, with manageable side effects and no dose-limiting toxicities. Patients will be closely monitored for safety throughout the trial.

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    Your information is confidential and used only for study enrollment purposes.








      Your information is confidential and used only for study enrollment purposes.








        Your information is confidential and used only for study enrollment purposes