Cutaneous Lupus Erythematosus Research Studies

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Do you have Skin Lupus?

When your butterfly rash becomes more than just an inconvenience, it’s time to consider a research study!

Cutaneous Lupus Erythematosus (CLE) is an autoimmune disease that causes red scaly rashes to appear on the skin.
We’re investigating a study drug that may be able to help improve skin conditions for people suffering from skin lupus with or without the presence of systemic lupus erythematosus.

You may be eligible to participate in the Skin Lupus Clinical Trials if you:

Are above the age of 18 years
Have been diagnosed with Chronic or Subacute Cutaneous Lupus
Have at least 1 active skin lupus rash anywhere on your body

Revival Research Institute is conducting clinical research trials on an investigational medication i.e. a subcutaneous injection, to observe its safety and efficacy on people who have skin rashes due to skin lupus. People with Systemic Lupus Erythematosus, who also have Cutaneous Lupus Erythematosus (Skin Lupus) are also eligible to participate in this research study.
*There is no cost to you or your private medical insurance to participate in this clinical research trial. You will be monetarily compensated for your time and travel. And all participants receive study-related care from doctors & health care professionals, free of cost.
*After filling the form, you may receive a phone call from one of our research staff. They may ask you personal questions about your health and medical history. Your information is completely safe and will not be disclosed to anyone that is not a part of the Revival Research Institute. For more information about our safe practices and your privacy, please visit our Privacy Policy.
*Your participation in our Skin Lupus study is completely voluntary, you are free to leave at any time. It will not cost you or your health insurance to be a part of the study or to leave it. All study-related care is completed free of cost and you will be reimbursed for your time and travel.

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About the Study

A total of 474 people will be randomly assigned to take part in the Skin Lupus Clinical Trials at approximately 225 locations, all around the world. This study is randomized, double-blind, and placebo-controlled, and it is divided into two parts:

Part A (Phase 2) is designed to confirm the efficacy of the study drug on human volunteers with Cutaneous Lupus Erythematosus
Part B (Phase 3) is designed to demonstrate the efficacy and safety of the study drug when compared to a placebo.

You may be assigned to any one of the parts, depending on the experience and the educated judgment of the study doctor.

Throughout the study, Revival Research’s experienced research staff will assess the drug’s tolerability by tracking any adverse events, clinical laboratory results, ECG findings, and vital signs. You may be eligible to apply if you are between ages 18-75 years and have a confirmed diagnosis of Cutaneous Lupus Erythematosus (Skin Lupus).

*Study drug and study-related care are provided at no cost to volunteers who are eligible for the study. If you are eligible, you will be contacted by a member of our research team. You may be asked to provide personal information about your entire medical history, overall health, and any medications you are taking.
*All volunteers who are potentially eligible for the research study will be provided with the study drug and study-related care at no cost. You may also be compensated for your travel and time. Participation does not necessitate the purchase of insurance.

Get Started: What to Expect?

We’re conducting this research to observe the safety and efficacy of the investigational drug that may be able to help people with Skin Lupus achieve skin improvement. Volunteers who are eligible for the Skin Lupus Clinical Trials will receive the study drug through subcutaneous injections. And the research study is completely free of cost to you. You don’t need health insurance to participate in our research study.

To see if you qualify for the research study, you may receive a phone call from one of our research staff members. They might invite you to the site location to complete the screening process to check if you are eligible to participate in the research study. You will be asked to sign an Informed Consent Form. The study doctor will take you through the document, explain everything about the research study and answer any questions you have about your involvement and the Skin Lupus clinical trials. We strongly encourage all volunteers to ask as many questions as they’d like about the research study before signing the Informed Consent Form.

*All participants qualified for the study will receive study-related care from healthcare professionals including doctors and nurses. After the screening process, if you qualify, you will either receive the study drug or the placebo (medication without the active ingredient of the study drug).

Condition

Cutaneous Lupus Erythematosus

Length of Study Treatment

24 weeks

Number of Study Visits

09

About Lupus

Systemic lupus is an autoimmune illness in which the immune system attacks and ruins the internal organs of the body. Cutaneous (skin) Lupus is a condition in which your immune system damages your skin cells. Skin lupus affects roughly 10% of all lupus cases, and it affects 65% of patients with systemic lupus. Women between the ages of 15 and 44 are significantly more likely to be diagnosed with lupus, accounting for over 90% of those diagnosed. SKIN Lupus may be subdivided based on its characteristics, which include acute, subacute and chronic cutaneous lupus.

Causes of Lupus

Although the specific source of lupus is unknown, most experts believe that it is caused by a combination of genetics and environmental factors.

Symptoms

Skin lupus symptoms are the same in all forms of the disease. They are red, scaly rashes that may be painful and itchy, but this does not always remain the case. They may improve or fade away in a matter of days or weeks, but they can also cause permanent disfigurement and loss of skin pigmentation.

Two prominent signs of Cutaneous Lupus (butterfly rash) are red scaly skin that may be round like a coin and a rash that runs over the cheekbones and across the bridge of the nose. About 50% of the population have this sort of rash.

Frequently Asked Questions

What are the treatment options for skin lupus?

Although there is no cure for lupus, treatments can help you feel better, improve your symptoms, and prevent flare-ups and other health issues. Some common medications include NSAIDs, corticosteroids, and in some cases chemotherapy.

Is Skin Lupus Contagious?

Lupus is not contagious. You can’t get it from another person, even if you have very close contact or sexual intercourse. Experts believe that it is caused by a combination of genes and environmental factors.

Can you have systemic and cutaneous lupus together?

Cutaneous Lupus (Skin Lupus) is occasionally diagnosed in people with systemic lupus erythematosus. SLE is an autoimmune disorder that affects joints and organs. However, skin lupus can develop without ever being diagnosed with systemic lupus.

I have SLE, can I volunteer for the Skin Lupus Study?

If you have skin lesions or rashes due to Cutaneous Lupus Erythematosus and have a Systemic Lupus Erythematosus (SLE) diagnosis, you may be eligible to participate in this study. The study team will screen potential volunteers for the study and will let you know if you are eligible.
With or without SLE, you need to have at least 1 active skin rash due to Skin lupus to be eligible to participate in the research study.

If I leave the research study, will I incur any costs?

Your participation in the research study is completely voluntary and free of cost to both you and your private health insurance. All volunteers who fulfill the criteria will be monetarily compensated for their time and travel.
If you do choose to leave the clinical trial at any time throughout the duration of the study, there will be no charges to you or your health insurance. And you will no longer be eligible to receive the study-related care, study drug, or stipends for the clinical trial.

Cutaneous Lupus